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In clients with pulmonary arterial hypertension, this may lead to vasodilation of your pulmonary vascular mattress and, to your lesser diploma, vasodilatation inside the systemic circulation .
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Once the NO/cGMP pathway is activated, as happens with sexual stimulation, inhibition of PDE5 by sildenafil brings about greater corpus cavernosum amounts of cGMP . Hence sexual stimulation is required to ensure that sildenafil to produce its meant effective pharmacological consequences .
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